Variation Browser
DownloadReceptor | Position | GPCRdb | Segment | Variant | Mutation type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|
Receptor | Position | GPCRdb | Segment | Variant | Mutation Type | Allele Frequency | Allele Count | Allele Number | Homozygotes | SIFT score | PolyPhen score | Functional annotation |
glp1r_human | 26 | N-term | Q => ArgfsTer25 | frameshift | 3.899e-05 | 1 | 25648 | 0 | None | None | ||
glp1r_human | 40 | N-term | R => Ter | stop gained | 2.498e-05 | 3 | 120108 | 0 | None | None | ||
glp1r_human | 131 | N-term | R => Ter | stop gained | 1.215e-05 | 1 | 82316 | 0 | None | None | ||
glp1r_human | 152 | 1.47x47 | TM1 | Y => Ter | stop gained | 8.274e-06 | 1 | 120858 | 0 | None | None | LB (polar (hydrogen bond), Van der Waals) |
glp1r_human | 190 | 2.60x60 | TM2 | R => Ter | stop gained | 8.237e-06 | 1 | 121400 | 0 | None | None | LB (polar (charge-assisted hydrogen bond), Van der Waals) |
glp1r_human | 241 | 3.44x44 | TM3 | Y => Ter | stop gained | 8.237e-06 | 1 | 121404 | 0 | None | None | SodiumPocket MicroSwitch LB (hydrophobic, Van der Waals, polar (hydrogen bond)) |
glp1r_human | 243 | 3.46x46 | TM3 | W => Ter | stop gained | 8.237e-06 | 1 | 121406 | 0 | None | None | |
glp1r_human | 269 | 4.45x46 | TM4 | Y => Ter | stop gained | 8.243e-06 | 1 | 121312 | 0 | None | None | |
glp1r_human | 315 | 5.45x45 | TM5 | F => LeufsTer5 | frameshift | 8.237e-06 | 1 | 121410 | 0 | None | None | |
glp1r_human | 446 | C-term | G => GlufsTer76 | frameshift | 8.247e-06 | 1 | 121256 | 0 | None | None | ||
glp1r_human | 5 | N-term | P => L | missense | 0.0003851 | 6 | 15580 | 0 | nan | 0.0 | ||
glp1r_human | 7 | N-term | P => L | missense | 0.4573 | 14194 | 31042 | 2489 | nan | 0.0 | ||
glp1r_human | 9 | N-term | R => C | missense | 7.266e-05 | 2 | 27524 | 0 | nan | 0.0 | ||
glp1r_human | 17 | N-term | M => T | missense | 0.0001085 | 3 | 27656 | 0 | nan | 0.0 | ||
glp1r_human | 20 | N-term | R => K | missense | 0.007527 | 202 | 26838 | 3 | nan | 0.0 | ||
glp1r_human | 26 | N-term | Q => K | missense | 3.89e-05 | 1 | 25708 | 0 | 0.07 | 0.004 | ||
glp1r_human | 33 | N-term | W => R | missense | 8.358e-06 | 1 | 119642 | 0 | 0.67 | 0.017 | ||
glp1r_human | 35 | N-term | T => M | missense | 1.667e-05 | 2 | 119950 | 0 | 0.32 | 0.945 | ||
glp1r_human | 40 | N-term | R => Q | missense | 5.827e-05 | 7 | 120130 | 0 | 0.08 | 0.046 | ||
glp1r_human | 43 | N-term | R => Q | missense | 1.666e-05 | 2 | 120032 | 0 | 0.53 | 0.004 | ||
glp1r_human | 44 | N-term | R => C | missense | 2.499e-05 | 3 | 120028 | 1 | 0.01 | 0.552 | ||
glp1r_human | 44 | N-term | R => H | missense | 0.003695 | 443 | 119880 | 12 | 0.18 | 0.001 | ||
glp1r_human | 45 | N-term | Q => H | missense | 8.344e-06 | 1 | 119840 | 0 | 0.0 | 0.578 | ||
glp1r_human | 48 | N-term | R => C | missense | 8.368e-06 | 1 | 119510 | 0 | 0.02 | 0.29 | ||
glp1r_human | 48 | N-term | R => H | missense | 5.021e-05 | 6 | 119508 | 0 | 0.64 | 0.001 | ||
glp1r_human | 53 | N-term | D => V | missense | 8.442e-06 | 1 | 118458 | 0 | 0.28 | 0.002 | ||
glp1r_human | 54 | N-term | P => S | missense | 3.399e-05 | 4 | 117680 | 0 | 0.01 | 0.747 | ||
glp1r_human | 56 | N-term | P => L | missense | 2.552e-05 | 3 | 117558 | 0 | 0.06 | 0.005 | ||
glp1r_human | 64 | N-term | R => Q | missense | 8.636e-06 | 1 | 115788 | 0 | 0.0 | 0.999 | ||
glp1r_human | 67 | N-term | D => N | missense | 1.722e-05 | 2 | 116146 | 0 | 0.01 | 1.0 | ||
glp1r_human | 70 | N-term | A => T | missense | 1.728e-05 | 2 | 115752 | 0 | 0.03 | 0.949 | ||
glp1r_human | 80 | N-term | F => L | missense | 9.335e-06 | 1 | 107120 | 0 | 0.29 | 0.008 | ||
glp1r_human | 81 | N-term | V => M | missense | 9.438e-06 | 1 | 105956 | 0 | 0.04 | 0.986 | ||
glp1r_human | 87 | N-term | W => R | missense | 4.225e-05 | 4 | 94668 | 0 | 0.0 | 0.928 | ||
glp1r_human | 101 | N-term | Y => C | missense | 3.91e-05 | 1 | 25578 | 0 | 0.01 | 0.919 | ||
glp1r_human | 124 | N-term | S => L | missense | 4.909e-05 | 3 | 61114 | 0 | 0.02 | 0.57 | ||
glp1r_human | 127 | N-term | E => K | missense | 1.452e-05 | 1 | 68872 | 0 | 0.07 | 0.081 | ||
glp1r_human | 130 | N-term | K => T | missense | 1.337e-05 | 1 | 74768 | 0 | 0.31 | 0.011 | ||
glp1r_human | 131 | N-term | R => Q | missense | 0.04483 | 3803 | 84832 | 294 | 0.46 | 0.0 | ||
glp1r_human | 132 | N-term | G => W | missense | 0.0007085 | 61 | 86102 | 0 | 0.07 | 0.998 | ||
glp1r_human | 132 | N-term | G => R | missense | 1.161e-05 | 1 | 86102 | 0 | 0.24 | 0.974 | ||
glp1r_human | 132 | N-term | G => A | missense | 9.243e-05 | 8 | 86548 | 0 | 0.45 | 0.729 | ||
glp1r_human | 137 | N-term | P => L | missense | 5.121e-05 | 6 | 117166 | 0 | 0.15 | 0.097 | ||
glp1r_human | 141 | 1.36x36 | TM1 | L => F | missense | 8.358e-06 | 1 | 119640 | 0 | 0.57 | 0.056 | LB (hydrophobic, Van der Waals) |
glp1r_human | 147 | 1.42x42 | TM1 | I => V | missense | 1.659e-05 | 2 | 120562 | 0 | 0.15 | 0.014 | |
glp1r_human | 149 | 1.44x44 | TM1 | T => M | missense | 8.283e-06 | 1 | 120724 | 0 | 0.0 | 0.976 | LB (Van der Waals) |
glp1r_human | 160 | 1.55x55 | TM1 | V => I | missense | 8.278e-06 | 1 | 120806 | 0 | 0.43 | 0.015 | |
glp1r_human | 161 | 1.56x56 | TM1 | I => F | missense | 8.281e-06 | 1 | 120754 | 0 | 0.01 | 0.702 | |
glp1r_human | 164 | 1.59x59 | TM1 | A => V | missense | 6.65e-05 | 8 | 120304 | 0 | 0.09 | 0.542 | |
glp1r_human | 167 | 1.62x62 | TM1 | L => F | missense | 8.329e-06 | 1 | 120066 | 0 | 0.01 | 0.133 | |
glp1r_human | 168 | 1.63x63 | TM1 | G => S | missense | 0.234 | 27986 | 119620 | 4045 | 0.31 | 0.036 | |
glp1r_human | 168 | 1.63x63 | TM1 | G => R | missense | 8.36e-06 | 1 | 119620 | 0 | 0.09 | 0.085 | |
glp1r_human | 171 | 12.49x49 | ICL1 | H => Q | missense | 8.363e-06 | 1 | 119574 | 0 | 0.07 | 0.984 | |
glp1r_human | 173 | 12.51x51 | ICL1 | H => R | missense | 4.163e-05 | 5 | 120094 | 0 | 0.22 | 0.059 | |
glp1r_human | 173 | 12.51x51 | ICL1 | H => P | missense | 8.327e-06 | 1 | 120094 | 0 | 0.0 | 0.921 | |
glp1r_human | 175 | 2.45x45 | TM2 | T => I | missense | 8.295e-06 | 1 | 120552 | 0 | 0.06 | 0.745 | |
glp1r_human | 176 | 2.46x46 | TM2 | R => W | missense | 1.652e-05 | 2 | 121080 | 0 | 0.0 | 1.0 | |
glp1r_human | 176 | 2.46x46 | TM2 | R => K | missense | 4.125e-05 | 5 | 121204 | 0 | 0.0 | 0.997 | |
glp1r_human | 180 | 2.50x50 | TM2 | H => Y | missense | 8.243e-06 | 1 | 121314 | 0 | 0.0 | 0.999 | |
glp1r_human | 190 | 2.60x60 | TM2 | R => Q | missense | 8.237e-06 | 1 | 121400 | 0 | 0.0 | 0.999 | LB (polar (charge-assisted hydrogen bond), Van der Waals) |
glp1r_human | 194 | 2.64x64 | TM2 | V => I | missense | 0.0004778 | 58 | 121400 | 0 | 0.36 | 0.06 | LB (Van der Waals, hydrophobic) |
glp1r_human | 194 | 2.64x64 | TM2 | V => A | missense | 3.295e-05 | 4 | 121402 | 0 | 0.0 | 0.672 | LB (Van der Waals, hydrophobic) |
glp1r_human | 199 | 2.69x69 | TM2 | A => T | missense | 8.238e-06 | 1 | 121394 | 0 | 0.32 | 0.01 | |
glp1r_human | 209 | ECL1 | A => T | missense | 8.245e-05 | 10 | 121292 | 1 | 0.66 | 0.017 | LB (Van der Waals) | |
glp1r_human | 216 | ECL1 | G => V | missense | 4.137e-05 | 5 | 120846 | 0 | 0.39 | 0.805 | ||
glp1r_human | 225 | 3.28x28 | TM3 | S => G | missense | 8.253e-06 | 1 | 121164 | 0 | 1.0 | 0.001 | |
glp1r_human | 227 | 3.30x30 | TM3 | R => C | missense | 8.247e-06 | 1 | 121250 | 0 | 0.0 | 0.997 | |
glp1r_human | 227 | 3.30x30 | TM3 | R => H | missense | 8.245e-06 | 1 | 121284 | 0 | 0.0 | 0.998 | |
glp1r_human | 231 | 3.34x34 | TM3 | L => P | missense | 8.239e-06 | 1 | 121370 | 0 | 0.0 | 0.958 | |
glp1r_human | 232 | 3.35x35 | TM3 | L => F | missense | 8.239e-06 | 1 | 121374 | 0 | 0.78 | 0.609 | |
glp1r_human | 238 | 3.41x41 | TM3 | A => V | missense | 1.647e-05 | 2 | 121400 | 0 | 1.0 | 0.043 | |
glp1r_human | 239 | 3.42x42 | TM3 | A => T | missense | 0.0001565 | 19 | 121402 | 0 | 0.02 | 0.893 | |
glp1r_human | 244 | 3.47x47 | TM3 | L => F | missense | 8.237e-06 | 1 | 121408 | 0 | 0.09 | 0.959 | |
glp1r_human | 249 | 3.52x52 | TM3 | V => M | missense | 9.06e-05 | 11 | 121408 | 0 | 0.11 | 0.103 | |
glp1r_human | 254 | 3.57x57 | TM3 | L => M | missense | 8.237e-06 | 1 | 121408 | 0 | 0.0 | 1.0 | GP (contact) |
glp1r_human | 257 | 3.60x60 | TM3 | F => I | missense | 8.237e-06 | 1 | 121408 | 0 | 0.28 | 0.11 | GP (contact) |
glp1r_human | 258 | ICL2 | S => L | missense | 8.237e-06 | 1 | 121408 | 0 | 0.04 | 0.557 | ||
glp1r_human | 259 | ICL2 | V => I | missense | 3.295e-05 | 4 | 121410 | 0 | 0.0 | 0.243 | ||
glp1r_human | 260 | ICL2 | L => F | missense | 0.5638 | 68417 | 121358 | 19287 | 1.0 | 0.004 | ||
glp1r_human | 261 | 4.37x38 | TM4 | S => A | missense | 8.238e-06 | 1 | 121396 | 0 | 0.05 | 0.688 | |
glp1r_human | 264 | 4.40x41 | TM4 | W => R | missense | 8.238e-06 | 1 | 121392 | 0 | 0.62 | 0.0 | |
glp1r_human | 268 | 4.44x45 | TM4 | L => F | missense | 0.000239 | 29 | 121356 | 0 | 0.02 | 0.826 | |
glp1r_human | 268 | 4.44x45 | TM4 | L => I | missense | 8.24e-06 | 1 | 121356 | 0 | 0.27 | 0.093 | |
glp1r_human | 270 | 4.46x47 | TM4 | V => M | missense | 2.473e-05 | 3 | 121302 | 0 | 0.03 | 0.44 | |
glp1r_human | 272 | 4.48x49 | TM4 | I => T | missense | 8.248e-06 | 1 | 121236 | 0 | 0.01 | 0.016 | |
glp1r_human | 285 | 4.61x61 | TM4 | G => S | missense | 8.243e-06 | 1 | 121320 | 0 | 0.14 | 0.958 | |
glp1r_human | 286 | 4.62x62 | TM4 | I => V | missense | 4.121e-05 | 5 | 121320 | 0 | 1.0 | 0.02 | LB (Van der Waals) |
glp1r_human | 287 | 4.63x63 | TM4 | V => D | missense | 8.242e-06 | 1 | 121326 | 0 | 0.0 | 0.988 | |
glp1r_human | 289 | 4.65x65 | TM4 | Y => C | missense | 8.242e-06 | 1 | 121326 | 0 | 0.34 | 1.0 | |
glp1r_human | 291 | 4.67x67 | TM4 | Y => C | missense | 8.242e-06 | 1 | 121324 | 0 | 0.0 | 0.959 | |
glp1r_human | 292 | 4.68x68 | TM4 | E => V | missense | 8.242e-06 | 1 | 121326 | 0 | 0.0 | 1.0 | |
glp1r_human | 293 | ECL2 | D => Y | missense | 1.648e-05 | 2 | 121328 | 0 | 0.0 | 0.998 | ||
glp1r_human | 294 | ECL2 | E => K | missense | 9.066e-05 | 11 | 121332 | 0 | 0.89 | 0.979 | ||
glp1r_human | 298 | 45.52x52 | ECL2 | T => A | missense | 1.648e-05 | 2 | 121384 | 0 | 0.15 | 0.519 | LB (Van der Waals, polar (hydrogen bond), polar (hydrogen bond with backbone)) |
glp1r_human | 302 | 5.32x33 | TM5 | N => Y | missense | 8.238e-06 | 1 | 121396 | 0 | 0.0 | 0.974 | |
glp1r_human | 310 | 5.40x40 | TM5 | R => W | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.984 | LB (polar (charge-assisted hydrogen bond), Van der Waals, polar (hydrogen bond with backbone)) |
glp1r_human | 310 | 5.40x40 | TM5 | R => Q | missense | 8.237e-06 | 1 | 121408 | 0 | 0.0 | 0.438 | LB (polar (charge-assisted hydrogen bond), Van der Waals, polar (hydrogen bond with backbone)) |
glp1r_human | 316 | 5.46x46 | TM5 | A => T | missense | 0.01048 | 1272 | 121410 | 16 | 0.01 | 0.977 | SodiumPocket MicroSwitch |
glp1r_human | 317 | 5.47x47 | TM5 | I => T | missense | 5.766e-05 | 7 | 121410 | 0 | 0.0 | 0.745 | |
glp1r_human | 320 | 5.50x50 | TM5 | N => Y | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.983 | |
glp1r_human | 326 | 5.56x56 | TM5 | R => W | missense | 8.237e-06 | 1 | 121406 | 0 | 0.0 | 0.999 | |
glp1r_human | 330 | 5.60x60 | TM5 | I => V | missense | 8.237e-06 | 1 | 121404 | 0 | 0.13 | 0.02 | GP (contact) |
glp1r_human | 331 | 5.61x61 | TM5 | V => M | missense | 1.647e-05 | 2 | 121404 | 0 | 0.0 | 0.894 | GP (contact) |
glp1r_human | 333 | 5.63x63 | TM5 | S => T | missense | 8.237e-06 | 1 | 121400 | 0 | 0.04 | 0.068 | GP (contact) |
glp1r_human | 333 | 5.63x63 | TM5 | S => C | missense | 4.119e-05 | 5 | 121400 | 0 | 0.0 | 0.914 | GP (contact) |
glp1r_human | 341 | 6.30x30 | TM6 | C => S | missense | 8.238e-06 | 1 | 121394 | 0 | 0.53 | 0.543 | PTM (ADP-ribosylation) GP (contact) |
glp1r_human | 342 | 6.31x31 | TM6 | K => Q | missense | 8.238e-06 | 1 | 121396 | 0 | 0.08 | 0.971 | GP (contact) |
glp1r_human | 344 | 6.33x33 | TM6 | D => E | missense | 0.0002719 | 33 | 121390 | 1 | 0.0 | 0.964 | GP (contact) |
glp1r_human | 355 | 6.44x44 | TM6 | T => I | missense | 1.665e-05 | 2 | 120132 | 0 | 0.02 | 1.0 | LB (polar (hydrogen bond), Van der Waals) |
glp1r_human | 357 | 6.46x46 | TM6 | I => F | missense | 8.297e-06 | 1 | 120530 | 0 | 0.0 | 0.999 | |
glp1r_human | 361 | 6.50x50 | TM6 | G => R | missense | 8.26e-06 | 1 | 121060 | 0 | 0.02 | 1.0 | |
glp1r_human | 363 | 6.52x52 | TM6 | H => Y | missense | 1.651e-05 | 2 | 121152 | 0 | 0.0 | 0.999 | |
glp1r_human | 367 | 6.56x56 | TM6 | F => L | missense | 8.247e-06 | 1 | 121256 | 0 | 0.0 | 0.998 | |
glp1r_human | 375 | ECL3 | A => T | missense | 1.648e-05 | 2 | 121342 | 0 | 0.21 | 1.0 | ||
glp1r_human | 376 | ECL3 | R => W | missense | 3.296e-05 | 4 | 121350 | 0 | 0.0 | 0.986 | ||
glp1r_human | 376 | ECL3 | R => Q | missense | 0.0009971 | 121 | 121358 | 0 | 1.0 | 0.851 | ||
glp1r_human | 376 | ECL3 | R => L | missense | 8.24e-06 | 1 | 121358 | 0 | 0.04 | 0.753 | ||
glp1r_human | 380 | 7.35x34 | TM7 | R => C | missense | 8.239e-06 | 1 | 121376 | 0 | 0.0 | 1.0 | LB (polar (charge-assisted hydrogen bond), Van der Waals) |
glp1r_human | 391 | 7.46x45 | TM7 | T => A | missense | 8.244e-06 | 1 | 121306 | 0 | 0.06 | 0.046 | LB (Van der Waals) |
glp1r_human | 401 | 7.56x56 | TM7 | L => I | missense | 8.293e-06 | 1 | 120582 | 0 | 0.0 | 0.996 | LB (polar (hydrogen bond with backbone), Van der Waals) |
glp1r_human | 408 | 8.49x49 | H8 | E => G | missense | 1.665e-05 | 2 | 120104 | 0 | 0.0 | 0.543 | GP (contact) |
glp1r_human | 414 | 8.55x55 | H8 | R => W | missense | 1.648e-05 | 2 | 121330 | 0 | 0.12 | 0.027 | |
glp1r_human | 414 | 8.55x55 | H8 | R => Q | missense | 1.648e-05 | 2 | 121336 | 0 | 0.43 | 0.019 | |
glp1r_human | 417 | 8.58x58 | H8 | W => G | missense | 8.241e-06 | 1 | 121350 | 0 | 0.01 | 0.697 | |
glp1r_human | 417 | 8.58x58 | H8 | W => L | missense | 1.648e-05 | 2 | 121356 | 0 | 0.04 | 0.543 | |
glp1r_human | 419 | 8.60x60 | H8 | R => H | missense | 8.239e-06 | 1 | 121374 | 0 | 0.01 | 0.912 | |
glp1r_human | 421 | 8.62x62 | H8 | R => W | missense | 0.0003872 | 47 | 121378 | 0 | 0.0 | 0.863 | |
glp1r_human | 421 | 8.62x62 | H8 | R => Q | missense | 0.002027 | 246 | 121378 | 2 | 0.25 | 0.042 | |
glp1r_human | 421 | 8.62x62 | H8 | R => P | missense | 1.648e-05 | 2 | 121378 | 0 | 0.0 | 0.847 | |
glp1r_human | 425 | 8.66x66 | H8 | L => S | missense | 8.238e-06 | 1 | 121394 | 0 | 0.21 | 0.063 | |
glp1r_human | 427 | 8.68x68 | H8 | I => N | missense | 8.238e-06 | 1 | 121396 | 0 | 0.49 | 0.002 | |
glp1r_human | 429 | 8.70x70 | H8 | R => K | missense | 8.237e-06 | 1 | 121398 | 0 | 0.15 | 0.383 | |
glp1r_human | 430 | 8.71x71 | H8 | D => E | missense | 8.238e-06 | 1 | 121396 | 0 | 0.38 | 0.057 | |
glp1r_human | 434 | C-term | K => T | missense | 8.238e-06 | 1 | 121386 | 0 | 0.13 | 0.588 | ||
glp1r_human | 435 | C-term | P => L | missense | 8.238e-06 | 1 | 121382 | 0 | 0.01 | 0.543 | ||
glp1r_human | 440 | C-term | T => A | missense | 7.415e-05 | 9 | 121370 | 0 | 0.41 | 0.001 | ||
glp1r_human | 443 | C-term | L => P | missense | 1.648e-05 | 2 | 121336 | 0 | 0.27 | 0.746 | ||
glp1r_human | 445 | C-term | S => T | missense | 0.002045 | 248 | 121262 | 1 | 0.14 | 0.312 | ||
glp1r_human | 449 | C-term | A => E | missense | 1.651e-05 | 2 | 121156 | 0 | 0.96 | 0.36 | ||
glp1r_human | 449 | C-term | A => V | missense | 1.651e-05 | 2 | 121156 | 0 | 0.57 | 0.001 | ||
glp1r_human | 450 | C-term | G => A | missense | 8.258e-06 | 1 | 121088 | 0 | 0.07 | 0.417 | ||
glp1r_human | 453 | C-term | M => T | missense | 8.263e-06 | 1 | 121024 | 0 | 0.73 | 0.009 |
Residue
- deleterious missense variants are shown in red
- tolerated missense variants are shown in green
- loss of function mutations ('stop gained' or 'frameshift' in the coding region) are shown in blue